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Nintendo was founded in 1889 as Nintendo Koppai[ c] by craftsman Fusajiro Yamauchi and originally produced handmade hanafuda playing cards. After venturing into various lines of business during the 1960s and acquiring a legal status as a public company, Nintendo distributed its first console, the Color TV-Game, in 1977.
A study found that ritonavir, a strong CYP3A4 and CYP2D6 inhibitor and moderate CYP1A2 inducer, increased trazodone peak levels by 1.34-fold, increased area-under-the-curve levels by 2.4-fold, and decreased the clearance of trazodone by 50%. [17] [12] This was associated with adverse effects such as nausea, hypotension, and syncope. [17]
Kenneth Cordele Griffin (born October 15, 1968) is an American hedge fund manager, entrepreneur and investor. He is the founder, chief executive officer, co- chief investment officer, and 80% owner of Citadel LLC, [ 1][ 2] a multinational hedge fund. He also owns Citadel Securities, one of the largest market makers in the United States.
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