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Polycystin 1. Polycystin 1 ( PC1) is a protein that in humans is encoded by the PKD1 gene. [ 5][ 6] Mutations of PKD1 are associated with most cases of autosomal dominant polycystic kidney disease, a severe hereditary disorder of the kidneys characterised by the development of renal cysts and severe kidney dysfunction. [ 7]
Proprotein convertases (PPCs) are a family of proteins that activate other proteins. Many proteins are inactive when they are first synthesized, because they contain chains of amino acids that block their activity. Proprotein convertases remove those chains and activate the protein. The prototypical proprotein convertase is furin. [ 1]
Abbrev. Meaning Latin (or Neo-Latin) origin ; a.c. before meals: ante cibum a.d., ad, AD right ear auris dextra a.m., am, AM morning: ante meridiem: nocte every night ...
The Parametron Computer 1 ( PC-1) was a binary, single-address computer developed at Professor Hidetosi Takahasi's Laboratory at the Department of Physics, University of Tokyo, [1] and was one of the first general purpose computers that used parametron components and dual frequency magnetic-core memory. Construction started in September 1957 ...
PCI Express x16. PCI Express x1. PCI Express x16. Conventional PCI (32-bit, 5 V) PCI Express ( Peripheral Component Interconnect Express ), officially abbreviated as PCIe or PCI-e, [ 1] is a high-speed serial computer expansion bus standard, designed to replace the older PCI, PCI-X and AGP bus standards.
About 0.17% to 0.89% (pre- COVID-19 pandemic) [ 9] Myalgic encephalomyelitis/chronic fatigue syndrome ( ME/CFS) is a disabling chronic illness. People with ME/CFS experience a profound fatigue that does not go away with rest, sleep issues and problems with memory or concentration. Further common symptoms include dizziness, nausea and pain. [ 3]
Caffeine is a central nervous system (CNS) stimulant of the methylxanthine class. [ 9] It is mainly used as a eugeroic ( wakefulness promoter) or as a mild cognitive enhancer to increase alertness and attentional performance. [ 10][ 11] Caffeine acts by blocking binding of adenosine to the adenosine A 1 receptor, which enhances release of the ...
Calpainopathy is the most common type of autosomal recessive limb-girdle muscular dystrophy (LGMD). [ 2] It preferentially affects the muscles of the hip girdle and shoulder girdle. No disease modifying pharmaceuticals have been developed as of 2019, although physical therapy, lifestyle modification, and orthopedic surgery can address symptoms.