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[22] [162] [163] The elderly are more sensitive to the side effects of benzodiazepines, and poisoning may even occur from their long-term use. [164] The various benzodiazepines differ in their toxicity; temazepam appears most toxic in overdose and when used with other drugs.
Symptoms. Effects of long-term benzodiazepine use may include disinhibition, impaired concentration and memory, depression, [ 19][ 20] as well as sexual dysfunction. [ 6][ 21] The long-term effects of benzodiazepines may differ from the adverse effects seen after acute administration of benzodiazepines. [ 22]
Diazepam. Diazepam, sold under the brand name Valium among others, is a medicine of the benzodiazepine family that acts as an anxiolytic. [ 14] It is used to treat a range of conditions, including anxiety, seizures, alcohol withdrawal syndrome, muscle spasms, insomnia, and restless legs syndrome. [ 14]
Benzodiazepine Side Effects. Benzodiazepines can cause side effects, including some that may affect your alertness, physical health and daily life. Common side effects of benzodiazepines include:
Benzodiazepine overdose ( BZD OD) describes the ingestion of one of the drugs in the benzodiazepine class in quantities greater than are recommended or generally practiced. The most common symptoms of overdose include central nervous system (CNS) depression, impaired balance, ataxia, and slurred speech.
Benzodiazepine withdrawal syndrome ( BZD withdrawal) is the cluster of signs and symptoms that may emerge when a person who has been taking benzodiazepines as prescribed develops a physical dependence on them and then reduces the dose or stops taking them without a safe taper schedule .
Prazepam is a benzodiazepine derivative drug developed by Warner-Lambert in the 1960s. [ 2] It possesses anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant properties. [ 3] Prazepam is a prodrug for desmethyldiazepam which is responsible for the therapeutic effects of prazepam.
Phenazepam is a drug of the benzodiazepine class. Benzodiazepine drugs contain a benzene ring fused to a diazepine ring, which is a seven membered ring with the two nitrogen constituents located at R1 and R4. The benzyl ring of phenazepam is substituted at R7 with a bromine group. Like most benzodiazepines, phenazepam has a phenyl ring in R5 ...