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Clomethiazole is a potent CYP2E1 enzyme inhibitor which slows down the metabolism of ethanol, hence its use in alcohol withdrawal. It is also an inhibitor of CYP2B6 and possibly CYP2A6 and thus can affect the plasma clearance of substrates of those enzymes. When clomethiazole is administered via IV in addition to carbamazepine, its clearance is ...
Alcohol withdrawal syndrome ( AWS) is a set of symptoms that can occur following a reduction in alcohol use after a period of excessive use. [ 1] Symptoms typically include anxiety, shakiness, sweating, vomiting, fast heart rate, and a mild fever. [ 1] More severe symptoms may include seizures, and delirium tremens (DTs); which can be fatal in ...
Alcoholic hallucinosis. Alcoholic hallucinosis is a complication of alcohol misuse in people with alcohol use disorder. [ 1][ 2] It can occur during acute intoxication or withdrawal with the potential of having delirium tremens. Alcohol hallucinosis is a rather uncommon alcohol-induced psychotic disorder almost exclusively seen in chronic ...
Chlordiazepoxide. Chlordiazepoxide, trade name Librium among others, is a sedative and hypnotic medication of the benzodiazepine class; it is used to treat anxiety, insomnia and symptoms of withdrawal from alcohol, benzodiazepines, and other drugs. Chlordiazepoxide has a medium to long half-life but its active metabolite has a very long half-life.
Alcohol detoxification (also known as detox) is the abrupt cessation of alcohol intake in individuals that have alcohol use disorder. This process is often coupled with substitution of drugs that have effects similar to the effects of alcohol in order to lessen the symptoms of alcohol withdrawal. When withdrawal does occur, it results in ...
Delirium tremens ( DTs; lit. 'mental disturbance with shaking') is a rapid onset of confusion usually caused by withdrawal from alcohol. [ 2] When it occurs, it is often three days into the withdrawal symptoms and lasts for two to three days. [ 2] Physical effects may include shaking, shivering, irregular heart rate, and sweating. [ 1]
Diazepam. Diazepam, sold under the brand name Valium among others, is a medicine of the benzodiazepine family that acts as an anxiolytic. [ 14] It is used to treat a range of conditions, including anxiety, seizures, alcohol withdrawal syndrome, muscle spasms, insomnia, and restless legs syndrome. [ 14]
Substance abuse, especially of alcohol and prescription drugs, for adults 60 and over is a fast-growing health problem in the U.S.. According to the 2022 National Survey on Drug Use and Health ...
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