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2. SNARE protein - Wikipedia

   en.wikipedia.org/wiki/SNARE_protein

   Cleavage of synaptobrevin affects the stability of the SNARE core by restricting it from entering the low energy conformation which is the target for NSF binding. This cleavage of synaptobrevin is the final target of TeNT and even in low doses the neurotoxin will inhibit neurotransmitter exocytosis. Role in neurotransmitter release

3. J. J. Bittenbinder - Wikipedia

   en.wikipedia.org/wiki/J._J._Bittenbinder

   J. J. Bittenbinder. John Joseph Bittenbinder (September 1, 1942 – May 26, 2023), known as J. J. Bittenbinder, was an American police officer, television host, and author. A member of the Chicago Police Department, he hosted the 1990s crime series Tough Target, and was a public speaker on the subject of safety.

4. Prime editing - Wikipedia

   en.wikipedia.org/wiki/Prime_editing

   Prime editing. Prime editing is a 'search-and-replace' genome editing technology in molecular biology by which the genome of living organisms may be modified. The technology directly writes new genetic information into a targeted DNA site. It uses a fusion protein, consisting of a catalytically impaired Cas9 endonuclease fused to an engineered ...

5. Off-target genome editing - Wikipedia

   en.wikipedia.org/wiki/Off-target_genome_editing

   To limit the rate of off-target cleavage, the therapy uses a highly specific and finely tuned TALEN, which has proven to have little-to-no background off-target interaction. CAR-T immunotherapy is an ex vivo procedure, which means that the patient's immune cells (in this case T-cells ) are extracted and edited using designer nucleases. [55]

6. Key points from CNN’s report on a missing binder full of ...

   www.aol.com/news/key-points-cnn-report-missing...

   During then-President Donald Trump’s final days in office, a 10-inch-thick binder of raw Russian intelligence transported from the CIA went missing after it was last seen at the White House, CNN ...

7. DNA-encoded chemical library - Wikipedia

   en.wikipedia.org/wiki/DNA-encoded_chemical_library

   DNA-encoded chemical library. DNA-encoded chemical libraries ( DECL) is a technology for the synthesis and screening on an unprecedented scale of collections of small molecule compounds. DECL is used in medicinal chemistry to bridge the fields of combinatorial chemistry and molecular biology. The aim of DECL technology is to accelerate the drug ...