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An arylcyclohexylamine is composed of a cyclohexylamine unit with an aryl moiety attachment. The aryl group is positioned geminal to the amine. In the simplest cases, the aryl moiety is typically a phenyl ring, sometimes with additional substitution. The amine is usually not primary; secondary amines such as methylamine or ethylamine, or ...
Eticyclidine (PCE, CI-400) is a dissociative anesthetic drug with hallucinogenic effects. It is similar in effects to phencyclidine but is slightly more potent. PCE was developed by Parke-Davis in the 1970s and evaluated for anesthetic potential under the code name CI-400, [2] but research into PCE was not continued after the development of ketamine, a similar drug with more favourable ...
Fluorexetamine ( 3'-Fluoro-2-oxo-PCE, 3-FXE) is a recreational designer drug from the arylcyclohexylamine family, with dissociative effects. It has reportedly been sold over the internet since around 2017, though has remained relatively uncommon. [ 1]
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Chemically, PCP is a member of the arylcyclohexylamine class, and pharmacologically, it is a dissociative anesthetic. [ 5][ 10][ 11] PCP works primarily as an NMDA receptor antagonist. [ 10] PCP is most commonly used in the United States. [ 12] While usage peaked in the US in the 1970s, [ 13] between 2005 and 2011 an increase in visits to ...
During menopause, your body and brain undergo some radical shifts that can contribute to the development of an eating disorder. New hormone fluctuations not only impact your sleep and mood, but ...
The Simmons–Smith reaction is an organic cheletropic reaction involving an organozinc carbenoid that reacts with an alkene (or alkyne) to form a cyclopropane. [ 1][ 2][ 3] It is named after Howard Ensign Simmons, Jr. and Ronald D. Smith. It uses a methylene free radical intermediate that is delivered to both carbons of the alkene ...
Ring-closing metathesis ( RCM) is a widely used variation of olefin metathesis in organic chemistry for the synthesis of various unsaturated rings via the intramolecular metathesis of two terminal alkenes, which forms the cycloalkene as the E- or Z- isomers and volatile ethylene. [ 1][ 2] The most commonly synthesized ring sizes are between 5-7 ...