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  2. Cholinergic - Wikipedia

    en.wikipedia.org/wiki/Cholinergic

    ISBN 978-0-444-52166-8. Cholinomimetics or cholinergic drugs are those drugs that cause effects similar to those resulting from introduction of acetylcholine, or simulation of ganglions of the parasympathetic nervous system. These drugs imitate action of endogenously released acetylcholine.

  3. Parasympathomimetic drug - Wikipedia

    en.wikipedia.org/wiki/Parasympathomimetic_drug

    A parasympathomimetic drug, sometimes called a cholinomimetic drug[ 1] or cholinergic receptor stimulating agent, [ 2] is a substance that stimulates the parasympathetic nervous system (PSNS). [ 3][ 2] These chemicals are also called cholinergic drugs because acetylcholine (ACh) is the neurotransmitter used by the PSNS. [ 1][ 4] Chemicals in ...

  4. Cholinergic blocking drug - Wikipedia

    en.wikipedia.org/wiki/Cholinergic_blocking_drug

    Cholinergic blocking drugs are a group of drugs that block the action of acetylcholine (ACh), a neurotransmitter, in synapses of the cholinergic nervous system. [1] They block acetylcholine from binding to cholinergic receptors, namely the nicotinic and muscarinic receptors. These agents have broad effects due to their actions in nerves located ...

  5. Neuromuscular-blocking drug - Wikipedia

    en.wikipedia.org/wiki/Neuromuscular-blocking_drug

    Neuromuscular-blocking drugs, or Neuromuscular blocking agents ( NMBAs ), block transmission at the neuromuscular junction, [ 1] causing paralysis of the affected skeletal muscles. This is accomplished via their action on the post-synaptic acetylcholine (Nm) receptors. In clinical use, neuromuscular block is used adjunctively to anesthesia to ...

  6. Cholinesterase inhibitor - Wikipedia

    en.wikipedia.org/wiki/Cholinesterase_inhibitor

    Cholinesterase inhibitors (ChEIs), also known as anti- cholinesterase, are chemicals that prevent the breakdown of the neurotransmitter acetylcholine or butyrylcholine. This increases the amount of the acetylcholine or butyrylcholine in the synaptic cleft that can bind to muscarinic receptors, nicotinic receptors and others.

  7. Cholinergic crisis - Wikipedia

    en.wikipedia.org/wiki/Cholinergic_crisis

    Flaccid paralysis resulting from cholinergic crisis can be distinguished from myasthenia gravis by the use of the drug edrophonium (Tensilon), as it only worsens the paralysis caused by cholinergic crisis but strengthens the muscle response in the case of myasthenia gravis. (Edrophonium is a cholinesterase inhibitor, hence increases the ...

  8. Nicotinic antagonist - Wikipedia

    en.wikipedia.org/wiki/Nicotinic_antagonist

    Nicotinic antagonist. A nicotinic antagonist is a type of anticholinergic drug that inhibits the action of acetylcholine (ACh) at nicotinic acetylcholine receptors. These compounds are mainly used for peripheral muscle paralysis in surgery, the classical agent of this type being tubocurarine, [ 1] but some centrally acting compounds such as ...

  9. Acetylcholine receptor - Wikipedia

    en.wikipedia.org/wiki/Acetylcholine_receptor

    The muscarine cholinergic receptor activates a G-protein when bound to extracellular ACh. The alpha subunit of the G-protein activates guanylate cyclase (inhibiting the effects of intracellular cAMP) while the beta-gamma subunit activates the K-channels and therefore hyperpolarize the cell. This causes a decrease in cardiac activity.

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