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This reaction is also known as the Skraup-Doebner-Von Miller quinoline synthesis, and is named after the Czech chemist Zdenko Hans Skraup (1850–1910), and the Germans Oscar Döbner (Doebner) (1850–1907) and Wilhelm von Miller (1848–1899).
RXNO:0000060. The Michaelis–Arbuzov reaction (also called the Arbuzov reaction) is the chemical reaction of a trivalent phosphorus ester with an alkyl halide to form a pentavalent phosphorus species and another alkyl halide. The picture below shows the most common types of substrates undergoing the Arbuzov reaction; phosphite esters ( 1 ...
Chemical synthesis ( chemical combination) is the artificial execution of chemical reactions to obtain one or several products. [ 1] This occurs by physical and chemical manipulations usually involving one or more reactions. In modern laboratory uses, the process is reproducible and reliable. A chemical synthesis involves one or more compounds ...
The Pictet–Spengler reaction is a chemical reaction in which a β-arylethylamine undergoes condensation with an aldehyde or ketone followed by ring closure. The reaction was first discovered in 1911 by Amé Pictet and Theodor Spengler (22 February 1886 – 18 August 1965). [ 1] Traditionally, an acidic catalyst in protic solvent was employed ...
Baeyer–Drewsen indigo synthesis. The Baeyer–Drewsen indigo synthesis (1882) is an organic reaction in which indigo is prepared from 2-nitrobenzaldehyde and acetone [ 1][ 2] The reaction was developed by von Baeyer and Viggo Drewsen [ da] in 1880 to produce the first synthetic indigo at laboratory scale. This procedure is not used at ...
RXNO:0000495. The Barton–Kellogg reaction is a coupling reaction between a diazo compound and a thioketone, giving an alkene by way of an episulfide intermediate. [1] [2] [3] The Barton–Kellogg reaction is also known as Barton–Kellogg olefination [4] and Barton olefin synthesis. [5]
The Wöhler synthesis is the conversion of ammonium cyanate into urea. This chemical reaction was described in 1828 by Friedrich Wöhler. [ 1] It is often cited as the starting point of modern organic chemistry. Although the Wöhler reaction concerns the conversion of ammonium cyanate, this salt appears only as an (unstable) intermediate.
Cascade reaction. Cascade reactions are often key steps in the efficient total synthesis of complex natural products. The key step in Heathcock 's synthesis of dihydroprotodaphniphylline features a highly efficient cascade involving two aldehyde/amine condensations, a Prins-like cyclization, and a 1,5-hydride transfer to afford a pentacyclic ...