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Eftilagimod alpha ("efti" in short) is a soluble LAG-3 fusion protein that activates antigen-presenting cells. It is a 160 kDa protein consisting of the four extracellular domains of LAG-3 fused to the Fc region of an IgG1 (LAG-3Ig). Efti binds preferentially to a subset of MHC class II molecules that are enriched in lipid rafts and/or composed ...
Lymphocyte-activation gene 3, also known as LAG-3, is a protein which in humans is encoded by the LAG3 gene. [5] LAG3, which was discovered in 1990 [6] and was designated CD223 (cluster of differentiation 223) after the Seventh Human Leucocyte Differentiation Antigen Workshop in 2000, [7] is a cell surface molecule with diverse biological effects on T cell function but overall has an immune ...
The Good Fight is an American legal drama produced for CBS's streaming service CBS All Access (later Paramount+). It is the platform's first original scripted series. [1] The series, created by Robert King, Michelle King, and Phil Alden Robinson, is a spin-off and sequel to The Good Wife, which was created by the Kings.
New York City had 420 heroin overdose deaths in 2013 — the most in a decade. A year ago, Vermont’s governor devoted his entire State of the State speech to heroin’s resurgence. The public began paying attention the following month, when Philip Seymour Hoffman died from an overdose of heroin and other drugs.
In molecular biology, the transcriptional activator LAG-3 is a transcriptional activator protein. The C. elegans Notch pathway, involved in the control of growth, differentiation and patterning in animal development, relies on either of the receptors GLP-1 or LIN-12. [1] Both these receptors promote signalling by the recruitment of LAG-3 to ...
The small piece of clay measures only 4.2 centimeters by 3.5 centimeters, it’s just 1.6 centimeters thick, and it weighs 28 grams. But despite its diminutive size, the tablet will help paint a ...
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A United Nations panel of human rights experts called on Belarus to release the Nobel Peace Prize-winning founder of the country's most respected rights group, who has been behind bars for three ...
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