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Chemically, PCP is a member of the arylcyclohexylamine class, and pharmacologically, it is a dissociative anesthetic. [ 5][ 10][ 11] PCP works primarily as an NMDA receptor antagonist. [ 10] PCP is most commonly used in the United States. [ 12] While usage peaked in the US in the 1970s, [ 13] between 2005 and 2011 an increase in visits to ...
An arylcyclohexylamine is composed of a cyclohexylamine unit with an aryl moiety attachment. The aryl group is positioned geminal to the amine. In the simplest cases, the aryl moiety is typically a phenyl ring, sometimes with additional substitution. The amine is usually not primary; secondary amines such as methylamine or ethylamine, or ...
Cyclohexylamine is used as an intermediate in synthesis of other organic compounds. It is the precursor to sulfenamide -based reagents used as accelerators for vulcanization. The amine itself is an effective corrosion inhibitor. It has been used as a flushing aid in the printing ink industry. [ 5]
In pharmacology, the term mechanism of action ( MOA) refers to the specific biochemical interaction through which a drug substance produces its pharmacological effect. [ 2] A mechanism of action usually includes mention of the specific molecular targets to which the drug binds, such as an enzyme or receptor. [ 3]
Lisdexamfetamine is a substituted amphetamine with an amide linkage formed by the condensation of dextroamphetamine with the carboxylate group of the essential amino acid L -lysine. [ 22] The reaction occurs with retention of stereochemistry, so the product lisdexamfetamine exists as a single stereoisomer.
The primary mechanism of phentermine's action in treating obesity is the reduction of hunger perception, which is a cognitive process mediated primarily through several nuclei within the hypothalamus (in particular, the lateral hypothalamic nucleus, arcuate nucleus, and ventromedial nucleus).
Phenylephrine is a selective α 1 -adrenergic receptor agonist with minimal to no β-adrenergic receptor agonist activity or induction of norepinephrine release. [ 5][ 8][ 15] It causes constriction of both arteries and veins. [ 12] Phenylephrine was patented in 1933 [ 16] and came into medical use in 1938. [ 17]
Procyclidine synthesis: [1] U.S. patent 2,826,590 Procyclidine, 1-cyclohexyl-1-phenyl-3-pyrrolidinopropan-1-ol, is synthesized in exactly the same manner as was seen for trihexyphenidyl, except this time the linear synthesis begins with the preparation of 3-(1-pyrrolidino)propiophenone.