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Alzheimer's disease ( AD) is a neurodegenerative disease that usually starts slowly and progressively worsens, [ 2] and is the cause of 60–70% of cases of dementia. [ 2][ 15] The most common early symptom is difficulty in remembering recent events. [ 1] As the disease advances, symptoms can include problems with language, disorientation ...
Worldwide the cost of dementia in 2015 was put at US$818 billion. People with dementia are often physically or chemically restrained to a greater degree than necessary, raising issues of human rights. [2] [272] Social stigma is commonly perceived by those with the condition, and also by their caregivers. [95]
The Montreal Cognitive Assessment ( MoCA) is a widely used screening assessment for detecting cognitive impairment. [ 1] It was created in 1996 by Ziad Nasreddine in Montreal, Quebec. It was validated in the setting of mild cognitive impairment (MCI), and has subsequently been adopted in numerous other clinical settings.
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[36] [37] [38] The Real-Time Quaking-Induced Conversion (RT-QuIC) assay has a diagnostic sensitivity of more than 80% and a specificity approaching 100%, tested in detecting PrP Sc in CSF samples of people with CJD. [39] [40] [41] It is therefore suggested as a high-value diagnostic method for the disease.
Amyloid beta ( Aβ or Abeta) denotes peptides of 36–43 amino acids that are the main component of the amyloid plaques found in the brains of people with Alzheimer's disease. [ 2] The peptides derive from the amyloid-beta precursor protein (APP), which is cleaved by beta secretase and gamma secretase to yield Aβ in a cholesterol-dependent ...
15 March – Neuroscientists report that mutations that enable people to naturally sleep as short as five hours reduce Alzheimer's pathology in mice. [ 243 ] [ 244 ] On 17 March, a study reports that longer and more frequent daytime naps appears to be associated with higher risk of Alzheimer's dementia.
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