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Serum iron. Serum iron is a medical laboratory test that measures the amount of circulating iron that is bound to transferrin and freely circulate in the blood. Clinicians order this laboratory test when they are concerned about iron deficiency, which can cause anemia and other problems. 65% of the iron in the body is bound up in hemoglobin ...
Ferritin is a universal intracellular protein that stores iron and releases it in a controlled fashion. The protein is produced by almost all living organisms, including archaea, bacteria, algae, higher plants, and animals. It is the primary intracellular iron-storage protein in both prokaryotes and eukaryotes, keeping iron in a soluble and non ...
Hemosiderin or haemosiderin is an iron -storage complex that is composed of partially digested ferritin and lysosomes. The breakdown of heme gives rise to biliverdin and iron. [ 1][ 2] The body then traps the released iron and stores it as hemosiderin in tissues. [ 3] Hemosiderin is also generated from the abnormal metabolic pathway of ferritin.
The affinity of transferrin for Fe(III) is extremely high (association constant is 10 20 M −1 at pH 7.4) [9] but decreases progressively with decreasing pH below neutrality. Transferrins are not limited to only binding to iron but also to different metal ions. [10] These glycoproteins are located in various bodily fluids of vertebrates.
LOINC. 2500-7, 14800-7, 35215-3. Total iron-binding capacity ( TIBC) or sometimes transferrin iron-binding capacity is a medical laboratory test that measures the blood's capacity to bind iron with transferrin. [ 1] Transferrin can bind two atoms of ferric iron (Fe 3+) with high affinity. It means that transferrin has the capacity to transport ...
Iron overload (also known as haemochromatosis or hemochromatosis) is the abnormal and increased accumulation of total iron in the body, leading to organ damage. [ 1] The primary mechanism of organ damage is oxidative stress, as elevated intracellular iron levels increase free radical formation via the Fenton reaction.
Serum ferritin levels reflect the iron stores available in the body. [4] The normal range is 20 to 200 ng/mL for men and 15 to 150 ng/mL for women. [8] Low levels (< 12 ng/mL) are specific for iron deficiency. [4] However, inflammatory and neoplastic disorders can cause ferritin levels to increase – this may be seen in cases of hepatitis ...
Under Sink Tiered Organizer (2 pack) $15 $25 Save $10. Get your bathroom and kitchen cabinets organized once and for all with a two-tiered organizer storage cabinet. This set of two means you can ...
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