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The most common side effects include urinary infections, nasopharyngitis, and upper respiratory tract infections . [5] [6] The most serious side effects include ketoacidosis (high blood levels of acids called ‘ketoacids’), pancreatitis (inflammation of the pancreas), hypersensitivity (allergic reactions) and hypoglycaemia (low blood sugar levels).
Empagliflozin, sold under the brand name Jardiance, among others, is an antidiabetic medication used to improve glucose control in people with type 2 diabetes. [ 10 ] [ 2 ] [ 12 ] It is taken by mouth .
Empagliflozin, approved in the United States in August 2014, under the brand name Jardiance by Boehringer Ingelheim. [30] Of the gliflozins, empagliflozin and tofogliflozin have the highest specificity for SGLT2 inhibition. [1] This oral medicine for type 2 diabetes has been shown to reduce the risk of cardiovascular death. [31]
Ipragliflozin (INN,: 69 trade names Suglat) is a pharmaceutical drug for treatment of type 2 diabetes. Ipragliflozin, jointly developed by Astellas Pharma and Kotobuki Pharmaceutical, was approved in Japan on January 17, 2014, and in Russia on May 22, 2019. Ipragliflozin is a Sodium/glucose cotransporter 2 (SGLT2) inhibitor .
Canagliflozin, sold under the brand name Invokana among others, is a medication used to treat type 2 diabetes. [3] It is used together with exercise and diet. [3] It is not recommended in type 1 diabetes. [3] It is taken by mouth. [3] Common side effects include vaginal yeast infections, nausea, constipation, and urinary tract infections. [3]
To reduce the risk of developing ketoacidosis (a serious condition where the body produces high levels of blood acids called ketones) after surgery, the FDA has approved changes to the prescribing information for SGLT2 inhibitor diabetes medications, recommending they be temporarily stopped before scheduled surgery.
Empagliflozin/metformin was approved for use in the European Union in May 2015. [5] Empagliflozin/metformin was approved for use in the United States in August 2015. [6] [11] The extended release version was approved for use in the United States in December 2016. [12] [13] Empagliflozin/metformin was approved for use in Australia in May 2020. [2]
Ertugliflozin. Ertugliflozin, sold under the brand name Steglatro, is a medication for the treatment of type 2 diabetes. [ 3][ 4] The most common side effects include fungal infections of the vagina and other infections of the female reproductive system. [ 4]
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